Building protection
 Threats, biochemical weapons, nerve agents
Biological aerosols
Biological Warfare Agents
Biological agents are defined as live organisms, or toxins that are derived from live organisms,
that are disseminated with the intention of causing disease in the target population. The difference
between the chemical weapons and the biological weapons is that the chemical agents cause direct injury;
the biological weapons cause disease, which results in injury.
Biological weapons may be selected from
Bacteria
Viruses
Rickettsiae
Yeasts and fungi
Toxins
Bacteria
The most widely known of disease causing agents. They include some of the most widely touted of
biological agents, including anthrax, and plague (the Black Death) meliodosis, brucellosis,
tularemia, and cholera.
Bacteria can be killed and controlled by disinfectants, boiling, and destroyed by sunlight. Some forms
however, such as anthrax and tetanus, are transformed into spores which have a great resistance to
disinfectants, boiling, and sunlight. Low temperatures and freezing do not affect bacteria. Bacteria
are visible only under a microscope, since their size ranges from 0.5 to 5.0 microns.
Viruses
Probably the group of pathogens that people are most aware of today, they include the agents
causing AIDS, hepatitis C, smallpox equine, encephalomyelitis, denque fever, yellow fever, and
psittacosis. These microbes are the smallest organisms. Their size is approximately a hundred
thousand times smaller than bacteria and they cannot be seen using an ordinary microscope. Unlike
bacteria, viruses require living tissue to multiply. Viruses are also resistant to drying and freezing.
Rickettsiae
Ricettsiae are a group of bacteria that have to live within a host cell. The diseases caused by
rickettsia that may be dispersed as a result of biological weapons are: Typhus, Q fever, Rocky Mountain
Spotted Fever, and Tsutsugamushi disease. These microbes are approximately the same size as bacteria but
require infected tissue to survive and reproduce.
Yeasts and fungi
The fungi that cause diseases are: coccidial mycosis, nocardiosis, and blastomycosis. Fungi are like
bacteria but are resistant to sunlight and more resistant to disinfectants.
Toxins
The toxins that cause disease that may be dispersed during wartime as a result of biological
weapons are: botulism, tetanus, and diptheria. Some microbes themselves are not poisonous but
produce toxins that are. Microbes that produce toxins that are poisonous are listed above. Although
there are over l,000 toxins that are able to produce damage to people, animals, and plants, only
a few can be delivered as biological weapons. Table 1 shows the mouse LD50s (lethal dose to half
of the exposed) of some toxins and nerve agents.
Table 1. Comparative lethality of selected toxins and nerve agents in laboratory mice.
| Agent |
LD50(µg/kg) |
Molecular weight |
Source |
| Botulinum Toxin |
0.001 |
150000 |
Bacterium |
| Shiga Toxin |
0.002 |
55000 |
Bacterium |
| Tetanus Toxin |
0.002 |
150000 |
Bacterium |
| Abrin |
0.04 |
65000 |
Plant |
| Maitotoxin |
0.10 |
3400 |
Marine dinoflagellate |
| Palytoxin |
0.15 |
2700 |
Marine soft coral |
| Ricin |
3 |
64000 |
Plant (castor bean) |
| Saxitoxin |
10 |
299 |
Marine dinoflagellate |
| VX |
15 |
267 |
Chemical agent |
| Soman (GD) |
64 |
182 |
Chemical agent |
| Sarin (GB) |
100 |
140 |
Chemical agent |
| T-2 Toxin |
1210 |
466 |
Fungal mycotoxin |
|